ISSN:
1432-1041
Keywords:
sparteine sulphate
;
diabetes mellitus
;
insulin secretion/-sensitivity
;
non-insulin dependent diabetes mellitus
;
arginine infusion
;
blood sugar level
;
glucose clamp technique
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Sparteine sulphate, given i.v. as a bolus of 15 mg/ml plus 90 mg in 0.9% NaCl 100 ml over 60 min, increases plasma insulin and decreases plasma glucose and adrenaline in non-insulin dependent (Type II) diabetic subjects. The hypoglycaemic effect was also evident in the presence of a high plasma glucose level produced by Biostator changing glucose infusion from 20.2±2.8 to 26.4±4.2 mg · kg−1 · min−1 (p〈0.01), and it was potentiated by simultaneous infusion of arginine. No additional effect of sparteine on the peripheral sensitivity to insulin were detected by the euglycaemic, hyperinsulinaemic glucose clamp technique, as the glucose infusion rate (3.1±0.8 vs 2.6±1.2 mg · kg−1 · min−1) was not statistically significant different in the last 60 min of the experiment. It is concluded that sparteine sulphate enhances β-cell secretion, causing a fall in the plasma glucose concentration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00540948
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