ISSN:
1573-6830
Keywords:
c-fos
;
egr-1
;
antisense oligodeoxynucleotides (ODNs)
;
amygdala kindling
;
immediate-early genes
;
ODN-induced toxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary 1. Amphetamine-induced c-fos andegr-1 expression in the striatum was used as a model in which to study the effects of antisense oligodeoxynucleotides (ODNs) directed at c-fos. Using direct infusions of ODNs into the striata of animals we have demonstrated that c-fos antisense ODNs retain most of their biological activity with 2- or 3-base substitutions. The c-fos antisense and mismatch ODNs attenuated Fos immunoreactivity but had little effect on Egr-1 immunoreactivity. 2. In another group of studies examining the role of c-fos in amygdala kindling, we have demonstrated that ODNs cause neurotoxic damage following repeated daily infusions into the amygdala. The damage observed was greatly diminished when the time interval between infusions was extended.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02088834
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