Publication Date:
2016-05-24
Description:
A structure–activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have been synthesized by cyclocondensation of the corresponding 3-dithiocarbamic flavanones under acidic conditions. The influence of different halogen substituents on the antibacterial properties has been tested against Staphylococcus aureus and Escherichia coli . Amongst the N , N -dialkylamino-substituted flavonoids, those having an N , N -diethylamino moiety exhibited good to excellent antimicrobial properties against both pathogens. Fluorine-substituted flavonoids were found to be less active than those bearing other halogen atoms. Beilstein J. Org. Chem. 2016, 12, 1065–1071. doi:10.3762/bjoc.12.100
Keywords:
antibacterial activitydithiocarbamatesdithiolium saltsflavonoidsSAR studies
Electronic ISSN:
1860-5397
Topics:
Chemistry and Pharmacology
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