ISSN:
1432-1041
Keywords:
converting enzyme inhibitor (CGS 14824A)
;
blood pressure
;
renin-angiotensin system
;
healthy volunteers
;
aldosterone
;
haemodynamic effects
;
plasma angiotensin II
;
angiotensin converting enzyme
;
plasma renin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary A new, orally active angiotensin converting enzyme (ACE) inhibitor, CGS 14824A, was evaluated in 12 healthy male volunteers. Two groups each of 6 volunteers were given 5 or 10 mg once daily p.o. for 8 days. Four hours after the first and the last morning doses, plasma angiotensin II, aldosterone and plasma converting enzyme activity had fallen, while blood angiotensin I and plasma renin activity had risen. Throughout the study, more than 90% inhibition of ACE was found immediately before giving either the 5 or 10 mg dose and 50% blockade was still present 72 h following the last dose. Based on the determination of ACE, there was no evidence of drug accumulation. No significant change in blood pressure or heart rate was observed during the course of the study. CGS 14824A was an effective, orally active, long-lasting and well tolerated converting enzyme inhibitor.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00541289
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