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  • angiotensin  (1)
  • electrophysiology  (1)
  • 1
    Digitale Medien
    Digitale Medien
    4-Aminopyridine and barium chloride attenuate the anti-epileptic effect of carbamazepine in hippocampal slices (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 254-257 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Carbamazepine ; potassium ; hippocampus ; epilepsy ; electrophysiology ; 4-aminopyridine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The exact mode of action of the anti-epileptic agent carbamazepine is unknown. In hippocampal slices in which epileptiform discharges were induced by addition of penicillin to the perfusion medium, the depressant effect of carbamazepine was attenuated by the potassium-channel blockers barium chloride (0.1 mM) and 4-aminopyridine (200 μM), which suggested that potassium fluxes might be involved in the mechanism of action of carbamazepine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01958152
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Angiotensin excites hippocampal pyramidal cells by two mechanisms (1982)
    Springer
    Cellular and molecular neurobiology 2 (1982), S. 21-32 
    Details
    ISSN: 1573-6830
    Schlagwort(e): angiotensin ; saralasin ; hippocampal slice
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary 1. The mechanism of action of angiotensins was studied on CA 1 pyramidal cells in hippocampal slices of the rat. Extracellular field potentials, single-cell action potentials, and intracellular excitatory and inhibitory postsynaptic potentials (epsps and ipsps) were recorded. 2. Angiotensin II and Des-Asp1-angiotensin II added to the perfusion fluid caused a dose-dependent increase in extracellularly recorded epsps and synaptically evoked population spikes. Either the neurons were depolarized by angiotensins and their firing frequency of action potentials increased or the membrane potential was unaffected. 3. Local application of angiotensins caused a depolarization associated with a conductance increase which was resistant to synaptic isolation. 4. Evoked and spontaneous inhibitory postsynaptic potentials were reduced by angiotensins, but the effects ofγ-aminobutyric acid (GABA) on soma and dendrites were unchanged. 5. All angiotensin effects were blocked by the specific antagonist Sar1, Ala8-angiotensin II (saralasin). 6. It is concluded that angiotensins excite CA 1 pyramidal cells by a direct and a disinhibitory mechanism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00735064
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
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