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  • lactitol  (2)
  • aminopyrine demethylation  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Postischemic ATP levels predict hepatic function 24 hours following ischemia in the rat (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 455-457 
    Details
    ISSN: 1420-9071
    Keywords: Liver ischemia ; hepatic function ; aminopyrine demethylation ; ATP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Hepatic function was assessed by the aminopyrine breath test (ABT) in male Sprague Dawley rats 24 h after partial hepatic ischemia. ABT decreased progressively to 26.3 (p〈0.05) and 19.7% of dose (p〈0.05) after 90 and 120 min of ischemia, respectively. ABT at 24 h after injury was correlated to the concentration of ATP in the ischemic lobes 1 h after the onset of reperfusion (r2=0.971) but not to ALT activity in plasma at 1 h (r2=0.391). We conclude that postischemic ATP levels are a better index of subsequent hepatic function than ALT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940546
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  • 2
    Electronic Resource
    Electronic Resource
    Lactitol: Gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 97-99 
    Details
    ISSN: 1432-1041
    Keywords: lactitol ; gastrointestinal absorption ; blood lactate ; cirrhosis ; metabolic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The gastrointestinal absorption of lactitol has been studied in 6 healthy volunteers and 8 patients with cirrhosis. Following administration of lactitol 0.5 g/kg, no lactitol was found in serum. The urinary excretion of lactitol over 24 h ranged from 0.1 to 1.4% of the administered dose (0.46% in cirrhotics and 0.35% in healthy volunteers). Blood D- and L-lactate and plasma glucose did not increase following lactitol. The data indicate that lactitol was poorly absorbed from the gastrointestinal tract in healthy volunteers and patients with cirrhosis, and that the disaccharide did not disturb glucose or lactate homeostasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555516
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of one month of lactitol treatment on calcium metabolism in man (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 205-207 
    Details
    ISSN: 1432-1041
    Keywords: lactitol ; calcium homeostasis ; osteocalcin ; parathormone ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The chronic use of lactitol as a food additive or laxative might adversely affect calcium homeostasis. Its effect on calcium metabolism has been examined in an open cross-over study in 12 volunteers given 20–40 g lactitol per day for one month. Compared to a control period without lactitol, the disaccharide did not alter the urinary excretion of calcium, inorganic phosphate or hydroxyproline, nor did it alter the circulating levels of calcium, phosphate, alkaline phosphatase, parathormone and osteocalcin. Chronic treatment with lactitol in laxative doses had no measurable effect on calcium metabolism in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558234
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