ISSN:
1573-4986
Keywords:
Lathyrus lectin/isolectins
;
structure-function relationship
;
amino acid sequences
;
blood group specificity
;
inhibition by sugars
;
interaction with hman serum glycoproteins
;
mitogenicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The structure-function relationship of eight structurally very similarLathyrus lectins, which are two-chain lectins from theVicieae tribe, has been studied. Hemagglutination activity, inhibition of hemagglutination, glycoprotein reactivity and mitogenic activity were determined for each of the lectins. Despite the close structural resemblance, marked differences in the carbohydrate binding activity of theLathyrus lectins were recorded. These functional differences were related to small conformational changes due to minor differences in amino acid sequence of eachLathyrus lectin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01048370
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