ISSN:
1432-1041
Keywords:
tienilic acid
;
hydrochlorothiazide
;
amiloride
;
blood pressure control
;
biochemical effects
;
serum uric acid
;
serum potassium
;
prolonged treatment
;
hypertension
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary A comparison has been made of arterial pressure and major metabolic parameters during long term treatment with tienilic acid and a hydrochlorothiazide-amiloride combination, using a randomized single-blind study without cross-over. A significant fall in systolic and diastolic blood pressure and no change in most biochemical parameters was observed with both drugs. Serum uric acid concentration was decreased during tienilic acid and was slightly increased whilst subjects took the hydrochlorothiazide-amiloride combination; serum potassium was slightly decreased on tienilic acid. No sign of hepatotoxicity was detected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542531
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