ISSN:
1573-8221
Keywords:
antiandrogens
;
median eminence of hypothalamus
;
lutinizing hormone (LH)
;
follicle-stimulating hormone (FSH)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of the antiandrogen 4-nitro-3-trifluoromethylisobutyranilide (flutamide, NFBA) on the plasma FSH, LH, and testosterone levels and on activity of steroid-Δ5-3β-ol dehydrogenase activity in the testes was studied in intact male rats and rats with destruction of the median eminence of the hypothalamus. In rats undergoing a mock operation and with the hypothalamus intact, NFBA increased the LH, FSH, and testosterone levels by five, two, and four times respectively, and enzyme activity by three to four times. After destruction of the median eminence the secretion of FSH was unchanged by NFBA, and the LH and testosterone levels and enzyme activity were increased by only 1.5–2 times, i.e., much less than in animals undergoing the mock operation. The results of these experiments indicate a leading role of the hypothalamus in the response of the pituitary and testis to the antiandrogen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00835594
Permalink
