ISSN:
1040-0397
Keywords:
Triazolobenzodiazepine
;
Voltammetry
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The electrochemical behavior of two novel triazolobenzodiazepines (adinazolam and U43.465F) has been studied in the pH range 3 to 13.5. Both compounds are reduced on the dropping mercury electrode and yield one reduction wave attributed to the azomethine group. The two-electron transfer is polarographically reversible. However, the transfer is followed by a fast conversion of the elearolysis product by a chemical reaction with an irreversible global process. A weak adsorption of the reactant has been observed under certain conditions. Quantitative analysis has been performed, showing that adinazolam and U43,465F can be determined up to 1.1 × 10-6M using differential pulse polarography.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140061121
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