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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 33 (1987), S. 81-83 
    ISSN: 1432-1041
    Keywords: glipizide ; nifedipine ; Type 2 diabetes ; hypoglycaemic action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six well controlled Type 2 diabetics who had received glipizide therapy ranging from 5 mg to 30 mg daily for at least the previous 2 months were studied. On Days 1 and 15 nifedipine 20 mg or placebo respectively were given in a random cross-over design after an overnight fast and with the morning dose of glipizide. Nifedipine did not influence the disposition of glipizide since there was no significant alteration in the maximum concentration, time to peak plasma concentration, elimination half-life or area under the curve. Neither did it have a major effect on plasma glucose or insulin although there was an early preprandial decrease in insulin level which reached significance at 1 h only (22.66 v 18.50 mIU/l).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 14 (1978), S. 39-46 
    ISSN: 1432-1041
    Keywords: Drugs ; prescribed ; children ; adults ; surveyed
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The drugs prescribed for children in Tayside hospitals in 1974 and 1975 were surveyed using the computer files of over 4000 children in each year. The results were compared with similar data on adult patients. Although similar proportions of both age groups received drugs, less than 3 drugs were prescribed for the great majority of the children (mean 2.5) compared with twice that number for adults. Seven classes of drugs accounted for almost four-fifths of the drugs prescribed for children but the same classes formed two-fifths only of the total drug use in adults. There was significantly greater use of antihistamine/sedative, anticonvulsant and decongestant/mucolytic drugs in children than in adults while the reverse was true for diuretics, KCl, cardioactive agents, sedatives/hypnotics, and tranquillisers. Antimicrobial drugs accounted for approximately one-third of the total drugs used in children and one half of all patients received at least one drug from this class. Penicillin preparations alone accounted for 65.1 per cent of all antimicrobial drug use. The percentage of children given ampicillin fell by almost half from 1974 to 1975 with a corresponding increase in the proportion receiving amoxycillin.
    Type of Medium: Electronic Resource
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