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  • Tumours  (2)
  • 1
    ISSN: 1435-604X
    Keywords: Mathematical model ; Laser surgery ; Optical fibres ; Tumours ; Thermal diffusion ; Multiple fibres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract A mathematical model is employed to discuss the region treated by local hyperthermia, when the source of heat is a laser whose energy is directed into the treatment region through four optical fibres ending at the corners of a square. If treatment is over a period that is substantially longer than the time for the temperature distribution to reach equilibrium, a steady state model using four point sources can be employed to obtain a general idea of the temperatures reached and the region treated for different power levels and sizes of square. For shorter times, and for more accurate estimation of the regions treated, numerical calculation on a computer is essential. The details of the calculation depend on individual cases, but we demonstrate here that such computations are possible, and present a series of typical results. A comparison is made with the results of a series of experiments on canine liver, showing that it is possible to obtain good qualitative and numerical agreement.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Lasers in medical science 4 (1989), S. 55-64 
    ISSN: 1435-604X
    Keywords: Laser hyperthermia ; Mathematical model ; Tumours ; Optical coefficients ; Optical fibres ; Thermal diffusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract A time dependent mathematical model of optical energy transfer and heat conduction in tissue with strong anisotropic scattering is used to analyse the results of experiments (1) in which the livers of rats were treated by local laser hyperthermia. Good qualitative agreement to the temperature distribution is possible, but satisfactory quantitative agreement is only possible if allowance is made for temperature dependence of the optical and thermal parameters. Analysis of the volume of tissue killed by the treatment shows a marked departure from the rule used in conventional hyperthermia to determine the region treated; the reason for this is not clear, but a number of possibilities are suggested.
    Type of Medium: Electronic Resource
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