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Suppressible alleles in a wide domain regulatory gene in Aspergillus nidulans (1984)

Taho, Nozha M. ; Sealy-Lewis, Heather M. ; Scazzocchio, Claudio

Springer

Current genetics 8 (1984), S. 245-251

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ISSN: 1432-0983

Keywords: Translation suppression ; Regulatory genes ; Aspergillus

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary The areA gene of Aspergillus nidulans is a one of the better studied eukaryotic wide domain regulatory genes, necessary for the expression of most structural genes involved in the utilization of a wide variety of nitrogen sources (Arst and Cove 1973; Arst 1983). Here we report the isolation and properties of areA alleles suppressible by translational suppressors (Roberts et al. 1979). Thus we show formally that the areA gene specifies a protein rather than an RNA product and we show that it is possible to generate by external suppression areA gene products with modified properties.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00419720

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