Publication Date:
1996-05-17
Description:
The vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurten, R C -- Cadena, D L -- Gill, G N -- CA58689/CA/NCI NIH HHS/ -- F32DK08666/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1996 May 17;272(5264):1008-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California, San Diego, La Jolla 92093-0650, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638121" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Carrier Proteins/chemistry/genetics/*metabolism
;
Cell Line
;
Cell Membrane/*metabolism
;
Down-Regulation
;
Endocytosis
;
Epidermal Growth Factor/pharmacology
;
HeLa Cells
;
Humans
;
Ligands
;
Lysosomes/*metabolism
;
Molecular Sequence Data
;
Molecular Weight
;
Receptor, Epidermal Growth Factor/*metabolism
;
Transfection
;
*Vesicular Transport Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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