ISSN:
0570-0833
Schlagwort(e):
Prostaglandins
;
Thromboxanes
;
Prostacyclins
;
Chemistry
;
General Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Prostaglandins continue to be a major and fast-developing area of research in the chemical and biological sciences. Increasing evidence has recently prompted some researchers to suggest that the important physiological actions of these hormones are exerted by their unstable arachidonic acid pathway intermediates, the endoperoxides, thromboxanes, and prostacyclin. The importance of these substances in physiology and medicine and the challenge they pose to synthetic chemistry place them in the forefront of chemical and biochemical investigation. Current biological research has greatly benefited by synthetic advances which have made available large quantities of some of these naturally occurring intermediates and several analogs with increased stabilities. Following a brief review of the primary prostaglandins, the present article describes recent biosynthetic developments, partial and total syntheses of prostaglandin endoperoxide analogs, thromboxane B2, and prostacyclins, and the biological properties of these molecules.
Zusätzliches Material:
20 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/anie.197802933
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