Publication Date:
1978-05-05
Description:
Skin test reactivity, lymphocyte transformation, and mononuclear cell tissue factor generation were evaluated both before and during systemic anticoagulation in 24 volunteers. Anticoagulation with warfarin decreased skin test induration and tissue factor generation, but lymphocyte trnasformation remained unchanged. An intact coagulation mechanism, including tissue factor generation, appears to be important for the development of skin test induration in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edwards, R L -- Rickles, F R -- New York, N.Y. -- Science. 1978 May 5;200(4341):541-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644314" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Antigens
;
Fibrin/metabolism
;
Humans
;
Hypersensitivity, Delayed/*physiopathology
;
Lymphocyte Activation/*drug effects
;
Mitogens
;
Skin Tests
;
Thromboplastin/*biosynthesis
;
Tuberculin
;
Warfarin/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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