ISSN:
1573-739X
Keywords:
Acitretin
;
Etretinate
;
Metabolism
;
Pharmacokinetics
;
Retinoids
;
Teratogens
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Acitretin was introduced as a replacement for etretinate, the ethyl ester of acitretin. Acitretin is eliminated at a much faster rate than etretinate. Although both drugs are teratogens, the replacement was important especially as it allowed for a much shorter post-medication period in which pregnancy should be precluded. Recent findings showed the presence of etretinate in the plasma of acitretin-treated patients. This article gives a review of known metabolic pathways of the retinoids and tries to elucidate the possible conversion of acitretin into etretinate after acitretin ingestion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01980479
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