ISSN:
0749-1581
Keywords:
Spirostan steroids
;
Tetrazole-substituted
;
1H NMR
;
Structural and conformational analysis
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The structures of two pairs of tetrazole-substituted spirostan steroids were characterized by the use of one- and two-dimensional 1H NMR measurements. The conformation of the seven-membered spirostan ring A of the steroid was determined by analysis of proton spin coupling constants and confirmed by 1D and 2D NOE experiments showing interactions between the methyl group and ring protons. The conformation of the tetrazole-substituted ring A was found to be the same for the four isomers, allowing them to be differentiated by the analysis of the effect of tetrazole-ring isomerization on the chemical shifts of neighbouring protons.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260290113
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