Publication Date:
1999-05-21
Description:
Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keppler, O T -- Hinderlich, S -- Langner, J -- Schwartz-Albiez, R -- Reutter, W -- Pawlita, M -- New York, N.Y. -- Science. 1999 May 21;284(5418):1372-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Applied Tumor Virology Program, Tumor Immunology Program, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10334995" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD/metabolism
;
Antigens, CD14/biosynthesis
;
Antigens, CD15/biosynthesis
;
Antigens, Differentiation, B-Lymphocyte/metabolism
;
Carbohydrate Epimerases/genetics/metabolism
;
Cell Adhesion Molecules/metabolism
;
Cell Membrane/*metabolism
;
Culture Media
;
*Escherichia coli Proteins
;
Glycoconjugates/*metabolism
;
HL-60 Cells
;
Histocompatibility Antigens Class I/biosynthesis
;
Humans
;
Lectins/metabolism
;
Oligosaccharides/biosynthesis
;
Rats
;
Sialic Acid Binding Ig-like Lectin 2
;
Sialic Acids/*biosynthesis
;
Transcription, Genetic
;
Transfection
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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