ISSN:
0749-1581
Keywords:
Cycloheximide
;
Sesbanimide A
;
Glutarimide
;
Antibiotic
;
Antitumour
;
1H NMR
;
1H—1H coupling constants
;
Difference NOE
;
Conformation
;
Hydrogen bonding
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 1H NMR spectra of the antibiotic cycloheximide in CDCl3 and CD3OD have been assigned. Analyses of coupling constants and difference NOE spectra showed different conformations in these two solvents, due to changeover between intra- and inter-molecular hydrogen bonding. The twist boat cyclohexanone found in the solid state was not detected in solution. The results are compared with the solution and solid-state conformations of the antitumour agent sesbanimide A.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260270704
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