Publication Date:
2004-01-17
Description:
A key priority for infectious disease research is to clarify how pathogen genetic variation, modulated by host immunity, transmission bottlenecks, and epidemic dynamics, determines the wide variety of pathogen phylogenies observed at scales that range from individual host to population. We call the melding of immunodynamics, epidemiology, and evolutionary biology required to achieve this synthesis pathogen "phylodynamics." We introduce a phylodynamic framework for the dissection of dynamic forces that determine the diversity of epidemiological and phylogenetic patterns observed in RNA viruses of vertebrates. A central pillar of this model is the Evolutionary Infectivity Profile, which captures the relationship between immune selection and pathogen transmission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grenfell, Bryan T -- Pybus, Oliver G -- Gog, Julia R -- Wood, James L N -- Daly, Janet M -- Mumford, Jenny A -- Holmes, Edward C -- BB/B524092/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2004 Jan 16;303(5656):327-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK. btg11@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14726583" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological
;
Animals
;
Antigenic Variation/genetics
;
Biological Evolution
;
*Disease Outbreaks/veterinary
;
Genetics, Population
;
Humans
;
Immunity
;
Mutation
;
*Phylogeny
;
Population Dynamics
;
RNA Virus Infections/*epidemiology/immunology/veterinary/*virology
;
RNA Viruses/*genetics/immunology/*pathogenicity/physiology
;
Selection, Genetic
;
Time Factors
;
Vaccination
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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