Publication Date:
1998-02-28
Description:
In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor beta and retinoid X receptors beta and gamma resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway. Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted. Thus, retinoid receptors are involved in the regulation of brain functions, and retinoic acid signaling defects may contribute to pathologies such as Parkinson's disease and schizophrenia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krezel, W -- Ghyselinck, N -- Samad, T A -- Dupe, V -- Kastner, P -- Borrelli, E -- Chambon, P -- New York, N.Y. -- Science. 1998 Feb 6;279(5352):863-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, College de France, Boite Postale 163, 67404 Illkirch Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9452386" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cocaine/pharmacology
;
Corpus Striatum/*metabolism
;
Dimerization
;
Dopamine/*metabolism
;
Locomotion
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
*Motor Activity/drug effects
;
Muscle, Skeletal/physiology
;
Parkinson Disease/etiology
;
Peripheral Nervous System/physiology
;
Receptors, Dopamine D1/genetics/metabolism
;
Receptors, Dopamine D2/genetics/metabolism
;
Receptors, Retinoic Acid/genetics/*physiology
;
Retinoid X Receptors
;
Schizophrenia/etiology
;
*Signal Transduction
;
Transcription Factors/genetics/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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