Publication Date:
2005-07-30
Description:
Calorie restriction (CR) extends the life span of numerous species, from yeast to rodents. Yeast Sir2 is a nicotinamide adenine dinucleotide (NAD+-dependent histone deacetylase that has been proposed to mediate the effects of CR. However, this hypothesis has been challenged by the observation that CR can extend yeast life span in the absence of Sir2. Here, we show that Sir2-independent life-span extension is mediated by Hst2, a Sir2 homolog that promotes the stability of repetitive ribosomal DNA, the same mechanism by which Sir2 extends life span. These findings demonstrate that the maintenance of DNA stability is critical for yeast life-span extension by CR and suggest that, in higher organisms, multiple members of the Sir2 family may regulate life span in response to diet.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamming, Dudley W -- Latorre-Esteves, Magda -- Medvedik, Oliver -- Wong, Stacy N -- Tsang, Felicia A -- Wang, Chen -- Lin, Su-Ju -- Sinclair, David A -- R01 AG024351/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1861-4. Epub 2005 Jul 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051752" target="_blank"〉PubMed〈/a〉
Keywords:
*Caloric Restriction
;
DNA, Fungal/genetics
;
DNA, Ribosomal/genetics
;
Gene Deletion
;
Gene Silencing
;
Genes, Fungal
;
Histone Deacetylases/genetics/physiology
;
*Longevity
;
Mutation
;
Niacinamide/pharmacology
;
Recombination, Genetic
;
Saccharomyces cerevisiae/genetics/*physiology
;
Saccharomyces cerevisiae Proteins/*genetics/*physiology
;
Silent Information Regulator Proteins, Saccharomyces cerevisiae/physiology
;
Sirtuin 2
;
Sirtuins/*genetics/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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