Publikationsdatum:
2012-04-21
Beschreibung:
Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362463/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362463/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pinheiro, Vitor B -- Taylor, Alexander I -- Cozens, Christopher -- Abramov, Mikhail -- Renders, Marleen -- Zhang, Su -- Chaput, John C -- Wengel, Jesper -- Peak-Chew, Sew-Yeu -- McLaughlin, Stephen H -- Herdewijn, Piet -- Holliger, Philipp -- BB/I004793/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- MC_U105178804/Medical Research Council/United Kingdom -- U.1051.03.006(78804)/Medical Research Council/United Kingdom -- U105178804/Medical Research Council/United Kingdom -- Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Apr 20;336(6079):341-4. doi: 10.1126/science.1217622.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22517858" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Aptamers, Nucleotide/*chemistry/genetics/*metabolism
;
DNA/chemistry/genetics
;
DNA-Directed DNA Polymerase/chemistry/genetics/metabolism
;
Directed Molecular Evolution
;
*Evolution, Molecular
;
*Molecular Mimicry
;
Nucleic Acids/*chemistry/genetics/metabolism
;
Polymers/*chemistry/metabolism
;
RNA/chemistry/genetics
;
RNA-Directed DNA Polymerase/chemistry/metabolism
;
Reverse Transcription
;
Templates, Genetic
;
Transcription, Genetic
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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