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  • Receptor-Ck expression  (1)
  • Receptor-‘C’k  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27) (1999)
    Springer
    Molecular and cellular biochemistry 200 (1999), S. 183-186 
    Details
    ISSN: 1573-4919
    Keywords: mevalonate pathway ; CDK inhibitors ; Receptor-Ck expression ; TPA ; HL-60 cell line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The present study was addressed to understand the interrelationship between Receptor-Ck induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27. Further, Receptor-Ck dependent signalling, known to control the mevalonate pathway, had a direct effect upon the p27 gene expression. Based upon these studies coupled with our earlier findings we propose that Receptor-Ck has an important role in the regulation of cell cycle machinery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006981614054
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence and nature of a novel thiol-oxidase in human platelets (1996)
    Springer
    Molecular and cellular biochemistry 159 (1996), S. 81-84 
    Details
    ISSN: 1573-4919
    Keywords: cholesterol ; Receptor-‘C’k ; thiol-oxidase ; platelets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The study, addressed to understand whether or not human platelets possess a unique thiol-oxidase whose activity could be modulated by signalling pathway initiated upon the activation of Receptor-‘C’k revealed the existence of disulphide-dependent oxidation within these cells and this phenomenon was regulated by Receptor-‘C’k-dependent generation of second messengers especially phosphatidic acid (PA); cAMP and cGMP. Purification of this activity revealed the existence of 47 kDa protein having thiol-oxidase activity. Keeping in view these results we propose that the existence of this novel 47 kDa Thiol-oxidase within human platelets may provide a ‘crucial switch’ for the regulation of Receptor-‘C’k-dependent mevalonate pathway in human platelets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226066
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    Paper (German National Licenses)
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