Publication Date:
1997-01-10
Description:
Interaction of the p55 tumor necrosis factor receptor 1 (TNF-R1)-associated signal transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated factor 2 protein (TRAF2) is required for activation of the nuclear transcription factor nuclear factor kappa B. TNF-induced activation of the stress-activated protein kinase (SAPK) was shown to occur through a noncytotoxic TRAF2-dependent pathway. TRAF2 was both sufficient and necessary for activation of SAPK by TNF-R1; conversely, expression of a dominant-negative FADD mutant, which blocks apoptosis, did not interfere with SAPK activation. Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Natoli, G -- Costanzo, A -- Ianni, A -- Templeton, D J -- Woodgett, J R -- Balsano, C -- Levrero, M -- New York, N.Y. -- Science. 1997 Jan 10;275(5297):200-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fondazione Andrea Cesalpino and Istituto di I Clinica Medica, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8985011" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcysteine/pharmacology
;
*Adaptor Proteins, Signal Transducing
;
Apoptosis
;
Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
;
Carrier Proteins/metabolism
;
Cell Line
;
Dactinomycin/pharmacology
;
Enzyme Activation
;
Fas-Associated Death Domain Protein
;
Free Radical Scavengers/pharmacology
;
HeLa Cells
;
Humans
;
JNK Mitogen-Activated Protein Kinases
;
*MAP Kinase Kinase Kinase 1
;
*Mitogen-Activated Protein Kinases
;
NF-kappa B/metabolism
;
Protein-Serine-Threonine Kinases/metabolism
;
Proteins/*metabolism
;
Reactive Oxygen Species/metabolism
;
Receptors, Tumor Necrosis Factor/*metabolism
;
Recombinant Proteins/pharmacology
;
Signal Transduction
;
TNF Receptor-Associated Factor 1
;
TNF Receptor-Associated Factor 2
;
Transfection
;
Tumor Necrosis Factor-alpha/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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