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  • Articles  (4)
  • Rapamycin biosynthesis  (2)
  • Streptomyces clavuligerus  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Solid state fermentation for cephalosporin production byStreptomyces clavuligerus andCephalosporium acremonium (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 1061-1065 
    Details
    ISSN: 1420-9071
    Keywords: Solid state fermentation ; β-lactam antibiotics ; cephalosporins ; Streptomyces clavuligerus ; Cephalosporium acremonium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Solid state fermentation systems were developed for the production of cephalosporins withStreptomyces clavuligerus andCephalosporium acremonium. S. clavuligerus NRRL 3585 was grown on moistened barley under optimum solid state fermentation conditions for 7 days; approximately 300 μg cephalosporins per g substrate were extracted from the kernels.C. acremonium C-10 produced approximately 950 μg cephalosporin C per g substrate after 10 days of solid state fermentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01950159
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  • 2
    Electronic Resource
    Electronic Resource
    Phosphate, ammonium, magnesium and iron nutrition ofStreptomyces hygroscopicus with respect to rapamycin biosynthesis (1995)
    Springer
    Journal of industrial microbiology and biotechnology 14 (1995), S. 424-427 
    Details
    ISSN: 1476-5535
    Keywords: Phosphate ; Ammonium ; Magnesium ; Iron ; Nutrition ; Rapamycin biosynthesis ; Streptomyces hygroscopicus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Phosphate, ammonium and magnesium salts interfered with rapamycin production byStreptomyces hygroscopicus at concentrations optimal for growth. These observations point to the existence of phosphorus, magnesium and nitrogen-negative regulation mechanisms for rapamycin biosynthesis. On the other hand, Fe2+ stimulated rapamycin production at concentrations greater than that required for growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01569962
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  • 3
    Electronic Resource
    Electronic Resource
    Carbon source nutrition of rapamycin biosynthesis inStreptomyces hygroscopicus (1995)
    Springer
    Journal of industrial microbiology and biotechnology 14 (1995), S. 436-439 
    Details
    ISSN: 1476-5535
    Keywords: Rapamycin biosynthesis ; Carbon sources ; Nutrition ; Streptomyces hygroscopicus ; Immunosuppressants ; Antibiotics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Chemically-defined media were developed for rapamycin production byStreptomyces hygroscopicus. Thirty-five carbon sources were tested for their effect on production. Eight failed to support growth and seven appeared to repress or inhibit rapamycin formation. The best combination of two carbon sources were 2% fructose and 0.5% mannose. Acetate and propionate, which are known to contribute most of the carbon atoms of the lactone ring, were unsatisfactory for growth and/or rapamycin production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01573954
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  • 4
    Electronic Resource
    Electronic Resource
    Dependence of nitrogen- and phosphorus-regulation of β-lactam antibiotic production byStreptomyces clavuligerus on aeration level (1995)
    Springer
    Journal of industrial microbiology and biotechnology 15 (1995), S. 407-410 
    Details
    ISSN: 1476-5535
    Keywords: nitrogen regulation ; phosphorus regulation ; cephamycin ; secondary metabolism ; antibiotics ; Streptomyces clavuligerus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Interference with β-lactam production inStreptomyces clavuligerus by ammonium and phosphate ions, normally observed with optimum levels of aeration, was eliminated by restriction of the air supply. Under such a restriction, ammonium slightly stimulated and phosphate markedly stimulated β-lactam antibiotic production. These are rare examples of ‘regulation reversal’ by an environmental modification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01569965
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