ISSN:
1432-2099
Keywords:
Key words Alpha-particle
;
Deuteron
;
Proton
;
Biophysical modelling
;
Radiosensitivity
;
Bacillus subtilis
;
Haploid yeast
;
Human diploid fibroblasts
;
DNA repair systems
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Physics
Notes:
Abstract Using knowledge of the track structure generated by ionizing particles together with details of the organisms being irradiated, the application of a new analytical method to two biophysical models to explain the inactivation of cells by radiation has been developed. It is shown that both models are equally successful in predicting experimental results and that good agreement is found with the data for single-strand phage, Bacillus subtilis spores, various strains of Escherichia coli, haploid and diploid yeast, and human diploid fibroblasts. The only significant discrepancy arose with T1-phage, for which a tentative explanation is offered. The differences in inherent radiosensitivity between organisms, after allowance is made for differences in target size, are attributed to differences in enzymatic repair systems and in the packing of the DNA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004110050165
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