Publication Date:
1992-12-11
Description:
Angiogenic factors produced by monocytes-macrophages are involved in the pathogenesis of chronic inflammatory disorders characterized by persistent angiogenesis. The possibility was tested that interleukin-8 (IL-8), which is a cytokine that is chemotactic for lymphocytes and neutrophils, is also angiogenic. Human recombinant IL-8 was potently angiogenic when implanted in the rat cornea and induced proliferation and chemotaxis of human umbilical vein endothelial cells. Angiogenic activity present in the conditioned media of inflamed human rheumatoid synovial tissue macrophages or lipopolysaccharide-stimulated blood monocytes was equally blocked by antibodies to either IL-8 or tumor necrosis factor-alpha. An IL-8 antisense oligonucleotide specifically blocked the production of monocyte-induced angiogenic activity. These data suggest a function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koch, A E -- Polverini, P J -- Kunkel, S L -- Harlow, L A -- DiPietro, L A -- Elner, V M -- Elner, S G -- Strieter, R M -- AR30692/AR/NIAMS NIH HHS/ -- AR41492/AR/NIAMS NIH HHS/ -- HL39926/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Dec 11;258(5089):1798-801.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1281554" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arthritis, Rheumatoid/physiopathology
;
Base Sequence
;
Cell Division/drug effects
;
Cells, Cultured
;
Chemotaxis/*drug effects
;
Cornea/*drug effects/physiology
;
Dose-Response Relationship, Drug
;
Endothelium, Vascular/drug effects/*physiology
;
Fibroblast Growth Factor 2/pharmacology
;
Humans
;
Interleukin-8/genetics/*pharmacology
;
Macrophages/*physiology
;
Mice
;
Molecular Sequence Data
;
Monocytes/physiology
;
*Neovascularization, Pathologic
;
Oligonucleotides, Antisense/*pharmacology
;
Rabbits
;
Rats
;
Recombinant Proteins/pharmacology
;
Synovial Fluid/physiology
;
Tumor Necrosis Factor-alpha/genetics
;
Umbilical Veins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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