ISSN:
1573-4978
Keywords:
arthritis
;
Mely
;
MMP-18
;
RASI-1
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Using homology-based database screening, we have identified the mouse homologue for the recently described matrix metalloproteinase-19 (MMP-19). Sequencing of mouse MMP-19 resulted in a putative open reading frame (ORF) of 527 amino acids showing 84% identity to the human homologue. In mouse, MMP-19 appears to be most highly expressed in the liver; however, there is a detectable level of expression in all tissues analyzed. The major mouse MMP-19 transcript is almost twice as long as that of human. The COOH-terminal serine and threonine-rich domain is considerably longer in the mouse homologue. The mouse MMP-19 gene maps to very distal end of mouse chromosome 10.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007196529604
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