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  • 1
    Online Resource
    Online Resource
    Studies of Epithelial Transporters and Ion Channels : Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 3 (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Human physiology. ; Medicine Research. ; Biology Research. ; Proteins . ; Biological transport. ; Cell membranes. ; Human Physiology. ; Biomedical Research. ; Protein Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells -- 2. Na+-K+-2Cl- Cotransporter -- 3. Thiazide-sensitive NaCl Cotransporter -- 4. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia -- 5. Na+/H+ Exchangers in Epithelia -- 6. Sugar Transport Across Epithelia -- 7. Amino Acid Transporters of Epithelia -- 8. Structure-Dynamic and Regulatory Specificities of Epithelial Na+/Ca2+ Exchangers (NCX) -- 9. Urea Transporters in Health and Disease -- 10. H,K-ATPases in Epithelia -- 11. Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells -- 12. Properties, Structure and Function of the Solute Carrier 26 Family of Anion Transporters -- 13. ClC-2 Chloride Channels -- 14. The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology -- 15. CFTR and Cystic Fibrosis: A Need for Personalized Medicine -- 16. Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator -- 17. TMEM16 Proteins (Anoctamins) in Epithelia -- 18. Epithelial Sodium Channels (ENaC) -- 19. ROMK and Bartter Syndrome Type 2 -- 20. Inwardly-rectifying K+ channel 4.1 regulates renal K+ excretion in the aldosterone-sensitive distal nephron -- 21. Small-molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels -- 22. KCa3.1 in Epithelia -- 23. BK Channels in Epithelia -- 24. Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ channels -- 25. KCNE regulation of KCNQ channels -- 26. Orai Channels -- 27. Trp Channels in Renal Epithelia -- 28. P2X receptors in Epithelia -- 29. The Polycystins and Polycystic Kidney Disease -- 30. Renal Aquaporins in Health and Disease.
    Abstract: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.
    Type of Medium: Online Resource
    Pages: XXI, 1244 p. 256 illus., 203 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030554545
    Series Statement: Physiology in Health and Disease,
    URL: https://doi.org/10.1007/978-3-030-55454-5
    DOI: 10.1007/978-3-030-55454-5
    DDC: 612
    Language: English
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  • 2
    Online Resource
    Online Resource
    Ion Transport Across Epithelial Tissues and Disease : Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 2 (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Human physiology. ; Medicine Research. ; Biology Research. ; Proteins . ; Biological transport. ; Cell membranes. ; Human Physiology. ; Biomedical Research. ; Protein Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. Organoids as a Model for Intestinal Ion Transport Physiology -- 2. Secretory Diarrhea -- 3. Role of the Epithelium in Diseases of the Intestine -- 4. Diseases of the Pancreas Involving Channels/Transporters -- 5. Fundamentals of Ion Transport across Human Sweat Gland in Health and Disease -- 6. Transporters in the Lactating Mammary Epithelium -- 7. Lipid Transport Across the Mammary Gland -- 8. Ion Transport across Inner Ear Epithelia -- 9. Regulation of Ion Transport through Retinal Pigment Epithelium: Impact in Retinal Degeneration -- 10. Ion Transport in the Choroid Plexus Epithelium -- 11. Transport Functions of Ectoderm Epithelial Cells Forming Dental Enamel. .
    Abstract: This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.
    Type of Medium: Online Resource
    Pages: XIX, 382 p. 77 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030553104
    Series Statement: Physiology in Health and Disease,
    URL: https://doi.org/10.1007/978-3-030-55310-4
    DOI: 10.1007/978-3-030-55310-4
    DDC: 612
    Language: English
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  • 3
    Online Resource
    Online Resource
    Basic Epithelial Ion Transport Principles and Function : Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 1 (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Human physiology. ; Medicine Research. ; Biology Research. ; Proteins . ; Biological transport. ; Cell membranes. ; Human Physiology. ; Biomedical Research. ; Protein Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. Techniques in Epithelial Transport -- 2. Understanding Transepithelial Current Measurements -- 3. Mathematical Modeling of Epithelial Ion Transport -- 4. Rationale of Epithelia Transport -- 5. Establishment of Epithelial Polarity -- 6. Molecular Mechanisms of Apical and Basolateral Sorting in Polarized Epithelial Cells -- 7. Membrane Protein Folding and Structure -- 8. Epithelial Ion Channel Folding and ER Associated Degradation (ERAD) -- 9. Fundamentals of Epithelial Cl- Transport -- 10. Fundamentals of Epithelial Na+ Absorption -- 11. Physiologic Influences of Transepithelial K+ Secretion -- 12. Volume Regulation in Epithelia -- 13. Fundamentals of Bicarbonate Secretion in Epithelia -- 14. Sexual Dimorphism of Epithelial Ion Channels -- 15. Non-coding RNA-Dependent Regulation of Channels/Transporters. .
    Abstract: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike. .
    Type of Medium: Online Resource
    Pages: XIX, 563 p. 106 illus., 71 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030527808
    Series Statement: Physiology in Health and Disease,
    URL: https://doi.org/10.1007/978-3-030-52780-8
    DOI: 10.1007/978-3-030-52780-8
    DDC: 612
    Language: English
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