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  • 1
    Electronic Resource
    Electronic Resource
    Microfabrication technology of flexible membrane based sensors for in vivo applications (1995)
    Weinheim : Wiley-Blackwell
    Electroanalysis 7 (1995), S. 846-851 
    Details
    ISSN: 1040-0397
    Keywords: Ion-selective electrodes ; Membrane sensors ; In vivo sensors ; pH ; Potassium ion ; Calcium ion sensors ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Potentiometric ion-sensitive planar microelectrode arrays, and amperornetric enzyme-containing biosensors were fabricated by photolithographic microelectronic technology on a flexible polyimide substrate. The steps of the microelectronics processing are summarized in more detail than previously described. The ion-selective electrodes were tested in blood serum, whole blood, and in the hamstring muscle of anesthetized rabbits. The test and performance characteristics of planar pH are emphasized, and K+, Na+, and Ca2+ data are included in this review. New applied results are presented from experiments where the electrodes have been implanted into an in situ porcine beating heart at the midmyocardial depth in order to monitor H+ and K+ changes during the course of coronary artery occlusion.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140070910
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  • 2
    Electronic Resource
    Electronic Resource
    Electroanalytical and biocompatibility studies on microfabricated array sensors (1995)
    Weinheim : Wiley-Blackwell
    Electroanalysis 7 (1995), S. 864-870 
    Details
    ISSN: 1040-0397
    Keywords: Biocompatibility ; Sensor arrays ; Ion selective electrodes ; Microfabrication ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: pH, potassium and calcium ion-selective membranes based on neutral ionophores TDDA, valinomycin and ETH-1001, respectively and immobilized in high molecular weight (HMW) and carboxylated poly(viny1 chloride) (PVC-COOH) as well as in aliphatic polyurethane (Tecoflex) matrices with normal and reduced amounts of plasticizers were investigated with respect of their general analytical properties, biocompatibility and cellular responses. The analytical performance of the PVC-COOH based potassium electrodes was not effected by reducing the plasticizer content from 66% (w/w) to 33% (w/w) while that of pH electrodes was significantly deteriorated at the lower plasticizer level. High molecular weight PVC and Tecoflex membranes with low plasticizer content induce less inflammatory response compared to membranes cast with high plasticizer concentrations or PVC-COOH as matrix. o-NPOE plasticized membranes are correlated with an increased acute, but a decireased chronic inflammatory response, when compared to membranes cast with DOS as plasticizer.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140070913
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  • 3
    Electronic Resource
    Electronic Resource
    Binding by derivatives of polyethylenimine: Effects of charge and structure of small molecules (1974)
    New York : Wiley-Blackwell
    Biopolymers 13 (1974), S. 791-796 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Apolar derivatives of polyethylenimine in aqueous solution have been shown previously to bind organic anions very strongly. These studies have been extended to other charged and noncharged small molecules, as well as to derivatives of polyethyl-enimine with much reduced positive charge. From these investigations the effects of charge and of structure of the small molecules can be assessed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1974.360130414
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