ISSN:
0170-2041
Keywords:
HIV-1 inhibition
;
Cysteine methyl ester, 2-methyl-
;
Oxazoles
;
Thiazolines
;
Polyangium spec.
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Using a biological screening with a HIV-1/MT-4 cell assay indicating antiviral activity and cell toxicity, we detected and isolated a new inhibiting metabolite from gliding bacteria, thiangazole (1). The structure of 1 was determined by spectroscopic methods to be a tris(thiazoline) derivative, showing a remarkable similarity to tantazole B (2). Chemical degradation and comparison with a synthetically prepared reference compound as well as with the degradation product from 2 furnished the (5R,8S,11S) configuration of the asymmetric centers in 1.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199219920163
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