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  • Plutonium  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 23 (1977), S. 141-145 
    ISSN: 1432-0827
    Keywords: Blood flow ; Femur ; Mouse ; Plutonium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The concentration of18F was measured in three parts of the femur and in the blood of 36 mice killed at intervals of from 1 min to 2 h after intravenous injection. Blood supply to the bone sections, calculated by dividing the increase in18F concentration in bone by the integral of18F concentration in blood between selected time intervals, was shown to be unaffected by the return of18F from bone to blood at times earlier than 90 min following injection. The supply of blood per unit mass of bone was greatest in distal end of the femur, less in proximal end and least in shaft. In whole femur average blood flow was 230 mm3 per gram fresh bone per min. The deposition of239Pu in the three parts of the mouse femur was shown to be linearly related to blood flow and the nature of the relationship is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 34 (1982), S. 416-421 
    ISSN: 1432-0827
    Keywords: Bone blood flow ; Mouse ; Plutonium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The rate at which blood is supplied to several bones in female CBA mice was calculated from18F measurements in bone and blood. Blood flow measurements were compared with plutonium uptake in whole bone and on endosteal and periosteal bone surfaces. The results showed that: (a) the rate at which blood is supplied to bone determines the rate of deposition of plutonium; (b) there is a threshold rate of blood supply below which plutonium is not deposited; and (c) the rate of blood supply determines the density of plutonium deposition on endosteal but not on periosteal bone surfaces. These results are discussed in the light of the current bone blood supply hypotheses.
    Type of Medium: Electronic Resource
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