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  • 1
    Electronic Resource
    Electronic Resource
    Identification of a binding region on Escherichia coli heat-stable enterotoxin to intestinal guanylyl cyclase C (1997)
    Springer
    International journal of peptide research and therapeutics 4 (1997), S. 1-11 
    Details
    ISSN: 1573-3904
    Keywords: Photoaffinity labeling ; Cross-linking ; p-Azidophenylalanine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The heat-stable enterotoxin (ST), produced by Escherichia coli, causes acute diarrhea in infants and domestic animals by activation of the intestinal membrane-bound receptor, guanylyl cyclase C. We have investigated a region on the ST molecule, which is recognized by the receptor, by introducing a photochromophore, p-azidophenylalanine (Pap), into three different regions of STp(4–17), which has the full toxic activity. Each ST analog bound to the receptor, but only STp(4–17) containing a Pap residue at position 11 in the central portion of the ST molecule, showed a high efficiency in the reaction which cross- linked with the receptor by UV radiation. These data clearly demonstrate that the region of the ST molecule encompassing the Asn11 residue directly interacts with the receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008846030577
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Identification of a binding region onEscherichia coli heat-stable enterotoxin to intestinal guanylyl cyclase C (1997)
    Springer
    International journal of peptide research and therapeutics 4 (1997), S. 1-11 
    Details
    ISSN: 1573-3904
    Keywords: Photoaffinity labeling ; Cross-linking ; p-Azidophenylalanine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The heat-stable enterotoxin (ST), produced byEscherichia coli, causes acute diarrhea in infants and domestic animals by activation of the intestinal membrane-bound receptor, guanylyl cyclase C. We have investigated a region on the ST molecule, which is recognized by the receptor, by introducing a photochromophore,p-azidophenylalanine (Pap), into three different regions of STp(4–17), which has the full toxic activity. Each ST analog bound to the receptor, but only STp(4–17) containing a Pap residue at position 11 in the central portion of the ST molecule, showed a high efficiency in the reaction which cross-linked with the receptor by UV radiation. These data clearly demonstrate that the region of the ST molecule encompassing the Asn11 residue directly interacts with the receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443549
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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