Publication Date:
1982-06-18
Description:
A current hypothesis suggests that alterations in the chemical composition and the subsequent changes in the structure of the membrane could account for the functional derangements observed in the hepatic mitochondria of animals fed ethanol for extended periods. An examination of this hypothesis reveals that the liver mitochondria of ethanol-fed rats show a dissociation between the respiratory functions and the lipid composition and microviscosity of the membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gordon, E R -- Rochman, J -- Arai, M -- Lieber, C S -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1319-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079764" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Ethanol/*pharmacology
;
Intracellular Membranes/drug effects/*metabolism/ultrastructure
;
Male
;
Membrane Lipids/analysis
;
Mitochondria, Liver/drug effects/*metabolism/ultrastructure
;
Oxygen Consumption/drug effects
;
Phospholipids/analysis
;
Rats
;
Rats, Inbred Strains
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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