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Inhibition of penicillin biosynthetic enzymes by halogen derivatives of phenylacetic acid (1994)

Martínez-Blanco, Honorina ; Reglero, Angel ; Luengo, José M.

Springer

Journal of industrial microbiology and biotechnology 13 (1994), S. 144-146

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ISSN: 1476-5535

Keywords: Penicillin ; Halogenated phenylacetic acid ; Antibiotic biosynthesis

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: Summary The effect of phenylacetic acid (PAA) and several analogs on the activity of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase (AT) fromPenicillium chrysogenum Wis 54-1255 has been tested. Whereas the substitution on the ring of a hydrogen atom by hydroxy-, methyl- or methoxy- groups did not cause any effect, the presence of halogens (Cl or Br) at positions 3 and/or 4 of PAA strongly inhibited these two enzymes. The replacement of hydrogen atoms by fluorine in certain positions also caused inhibition, but to a lesser extent.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01583998

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