ISSN:
1573-4986
Keywords:
Pseudomonas aeruginosa adherence
;
lectin interactions
;
glycosphingolipid antigens
;
ABO blood group
;
P system antigens
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Pseudomonas aeruginosa may cause serious infections in most human tissues/organs. Its adherence to them is mediated by a battery of adhesins including the PA-I and PA-II lectins, which are produced in this bacterium in high quantities. PA-I binds to thed-galactose of the erythrocyte glycosphingolipids exhibiting highest affinities for B and Pk (followed by P1) antigens, while PA-II preferentially binds to thel-fucose of H, A and B antigens. IntactP. aeruginosa cells also exhibit a clear Pk and P1 over p preference. Such affinities for the most common human ABH and P system antigens may underlie the widespread tissue infectivity and pathogenicity of this bacterium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00731276
Permalink