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Zur Rekonstruktion der Philosophischen Hermeneutik (1995)

Krämer, Hans

Springer

Journal for general philosophy of science 26 (1995), S. 169-185

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ISSN: 1572-8587

Keywords: (Anti)Realism ; interpretationism ; semiotics ; mono-/polysemy ; anthropology ; truth ; hermeneutical circle ; preconception (prejudice) ; principle of charity ; fallibilism ; criteria of truth and objectivity ; fictional and informative systems of signs ; author's intention

Source: Springer Online Journal Archives 1860-2000

Topics: Philosophy , Nature of Science, Research, Systems of Higher Education, Museum Science

Notes: Summary Towards a reconstruction of philosophical hermeneutics. Following Nietzsche, Heidegger and, on the other hand, Cassirer and Wittgenstein, a philosophy of interpretation, i.e. a relativism of world-views, is at present increasing in continental as well as in analytical philosophy. From the basis of a critical fallibilism the shortcomings of the new epistemological antirealism are pointed out in general, and, hence, consequences are drawn for the more specialized case of metahermeneutics (hermeneutics being defined as a sort of pragmatical semiotics). A combination of realistic and antirealistic elements is recommended as unevitable. According to this, firstly, the key-concepts of hermeneutics must be differentiated, and, secondly, a fundamental set of criteria can be established that bridges the gap between metahermeneutics and hermeneutical practice.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01130933

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rac-altersolanol A and related tetrahydroanthraquinones, total synthesis and cytotoxic properties (1988)

Krohn, Karsten ; Markus, Helga ; Kraemer, Hans Peter ; [et al.]

Weinheim : Wiley-Blackwell

Liebigs Annalen 1988 (1988), S. 1033-1041

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ISSN: 0170-2041

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: rac-Altersolanol A und verwandte Tetrahydroanthrachinone. Totalsynthese und cytotoxische EigenschaftenEin Schlüsselschritt der ersten Synthese des racemischen Altersolanols A (1a) ist die regioselektive Diels-Alder-Reaktion von 5-Acetoxy-7-methoxy-1,4-naphthochinon (12) mit 2-Methyl-1-(trimethylsiloxy)-1,3-butadien (13) zum Addukt 14, dessen Struktur durch Röntgenstrukturanalyse bestätigt wird. Die Hydroxygruppen des Ringes A werden durch Epoxidierung von 14 zu 20, Umlagerung zum Allylalkohol 26, erneute Epoxidierung zu 31 und Öffnung des Oxirans zu rac-Altersolanol A (1a) eingeführt. Ähnliche Produkte werden ausgehend von Juglon (15) erhalten. Viele der intermediären Epoxide, aber auch Verbindungen 42-44, zeigten bemerkenswerte cytotoxische Eigenschaften, jedoch waren alle Verbindungen für eine mögliche Anwendung als Antitumormittel zu toxisch.

Notes: A key step in the first synthesis of racemic altersolanol A (1a) is the regioselective Diels-Alder reaction of 5-acetoxy-7-methoxy-1,4-naphthoquinone (12) with 2-methyl-1-(trimethylsiloxy)-1,3-butadiene (13) to afford the adduct 14. The structure of 14 has been confirmed by X-ray measurements. The hydroxy groups of ring A are introduced by epoxidation of 14 to 20, rearrangement to the allylic alcohol 26, epoxidation to 31, and opening of the oxirane to rac-altersolanol A (1a). Similar products were obtained starting from juglone (15). Many of the intermediate epoxides and also compounds 42-44 show remarkable cytotoxicity in cell cultures but all compounds were too toxic to be useful as anticancer agents.

Additional Material: 3 Tab.