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  • Nucleic acid amplification, Cell biology, RNA characterisation and manipulation  (1)
  • minimizing sequences  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of nonlinear science 1 (1991), S. 17-70 
    ISSN: 1432-1467
    Keywords: nonlinear partial differential equations ; minimizing sequences ; loss of ellipticity ; fine structure ; phase transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Summary We investigate models for the dynamical behavior of mechanical systems that dissipate energy as timet increases. We focus on models whose underlying potential energy functions do not attain a minimum, possessing minimizing sequences with finer and finer structure that converge weakly to nonminimizing states. In Model 1 the evolution is governed by a nonlinear partial differential equation closely related to that of one-dimensional viscoelasticity, the underlying static problem being of mixed type. In Model 2 the equation of motion is an integro—partial differential equation obtained from that in Model 1 by an averaging of the nonlinear term; the corresponding potential energy is nonlocal. After establishing global existence and uniqueness results, we consider the longtime behavior of the systems. We find that the two systems differ dramatically. In Model 1, for no solution does the energy tend to its global minimum ast → ∞. In Model 2, however, a large, dense set of solutions realize global minimizing sequences; in this case we are able to characterize, asymptotically, how energy escapes to infinity in wavenumber space in a manner that depends upon the smoothness of initial data. We also briefly discuss a third model that shares the stationary solutions of the second but is a gradient dynamical system. The models were designed to provide insight into the dynamical development of finer and finer microstructure that is observed in certain material phase transformations. They are also of interest as examples of strongly dissipative, infinite-dimensional dynamical systems with infinitely many unstable “modes”, the asymptotic fate of solutions exhibiting in the case of Model 2 an extreme sensitivity with respect to the initial data.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2013-08-28
    Description: Efficient tissue-specific delivery is a crucial factor in the successful development of therapeutic oligonucleotides. Screening for novel delivery methods with unique tissue-homing properties requires a rapid, sensitive, flexible and unbiased technique able to visualize the in vivo biodistribution of these oligonucleotides. Here, we present whole body scanning PCR, a platform that relies on the local extraction of tissues from a mouse whole body section followed by the conversion of target-specific qPCR signals into an image. This platform was designed to be compatible with a novel RT-qPCR assay for the detection of siRNAs and with an assay suitable for the detection of heavily chemically modified oligonucleotides, which we termed Chemical-Ligation qPCR (CL-qPCR). In addition to this, the platform can also be used to investigate the global expression of endogenous mRNAs and non-coding RNAs. Incorporation of other detection systems, such as aptamers, could even further expand the use of this technology.
    Keywords: Nucleic acid amplification, Cell biology, RNA characterisation and manipulation
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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