Publication Date:
1980-10-10
Description:
Rats maintained on a 12-hour light-dark cycle were tested for pain sensitivity after being deprived of food during either the dark or the light phase of the cycle. Diurnal fluctuations in pain sensitivity were observed. The fluctuations followed food intake patterns rather than a natural circadian rhythm, with food deprivation producing a decrease in pain sensitivity. The analgesic response produced by this mild food deprivation was strongly attenuated by naloxone or feeding, suggesting that endogenous opioid systems may be related to patterns of food intake.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGivern, R F -- Berntson, G G -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):210-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7191143" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Circadian Rhythm
;
Endorphins/antagonists & inhibitors/*physiology
;
Feeding Behavior/*physiology
;
Food Deprivation
;
Male
;
Naloxone/*pharmacology
;
Pain/*physiopathology
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
