Publication Date:
2010-10-23
Description:
Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, the origin of adult microglia remains controversial. We show that postnatal hematopoietic progenitors do not significantly contribute to microglia homeostasis in the adult brain. In contrast to many macrophage populations, we show that microglia develop in mice that lack colony stimulating factor-1 (CSF-1) but are absent in CSF-1 receptor-deficient mice. In vivo lineage tracing studies established that adult microglia derive from primitive myeloid progenitors that arise before embryonic day 8. These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719181/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719181/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ginhoux, Florent -- Greter, Melanie -- Leboeuf, Marylene -- Nandi, Sayan -- See, Peter -- Gokhan, Solen -- Mehler, Mark F -- Conway, Simon J -- Ng, Lai Guan -- Stanley, E Richard -- Samokhvalov, Igor M -- Merad, Miriam -- AI080884/AI/NIAID NIH HHS/ -- CA112100/CA/NCI NIH HHS/ -- CA26504/CA/NCI NIH HHS/ -- CA32551/CA/NCI NIH HHS/ -- HL086899/HL/NHLBI NIH HHS/ -- MH66290/MH/NIMH NIH HHS/ -- NS38902/NS/NINDS NIH HHS/ -- P60 DK020541/DK/NIDDK NIH HHS/ -- R01 CA032551/CA/NCI NIH HHS/ -- R01 HL060714/HL/NHLBI NIH HHS/ -- R01 HL060714-13/HL/NHLBI NIH HHS/ -- R37 CA026504/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2010 Nov 5;330(6005):841-5. doi: 10.1126/science.1194637. Epub 2010 Oct 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA. Florent_ginhoux@immunol.a-star.edu.sg〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20966214" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/*cytology/embryology
;
Cell Differentiation
;
Cell Lineage
;
Cell Proliferation
;
Core Binding Factor Alpha 2 Subunit/genetics/metabolism
;
Embryo, Mammalian/cytology/physiology
;
Female
;
Gene Knock-In Techniques
;
Hematopoiesis
;
Hematopoietic Stem Cells/cytology
;
Homeostasis
;
Macrophage Colony-Stimulating Factor/metabolism
;
Macrophages/*cytology
;
Mice
;
Mice, Inbred C57BL
;
Microglia/*cytology
;
Myeloid Progenitor Cells/*cytology
;
Receptor, Macrophage Colony-Stimulating Factor/metabolism
;
Yolk Sac/cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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