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Convenient lipase-assisted preparation of both enantiomers of suprofen, a non-steroidal anti-inflammatory drug (1996)

Mertoli, Patrizia ; Nicolosi, Giovanni ; Patti, Angela ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Chirality 8 (1996), S. 377-380

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ISSN: 0899-0042

Keywords: NSAIDs ; esterification ; resolution ; Candida antarctica lipase ; Mucor miehei lipase ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The resolution of rac-suprofen (1) catalysed by lipase in organic solvents was investigated. Direct esterification of rac-1 with methanol in dichorometane catalysed by Novozym® 435 furnished the pharmacologically active (+)-(S)-suprofen as unreacted product with excellent enantiomeric excess. The same procedure in toluene using Mucor miehei lipase adsorbed in Celite as catalyst afforded (-)-(R)-suprofen with good optical purity. © 1996 Wiley-Liss, Inc.

Additional Material: 1 Ill.

Type of Medium: Electronic Resource

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