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    Epigenetic dynamics of imprinted X inactivation during early mouse development (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-13
    Description: The initiation of X-chromosome inactivation is thought to be tightly correlated with early differentiation events during mouse development. Here, we show that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation. A reversal of the inactive state, with a loss of epigenetic marks such as histone modifications and polycomb proteins, subsequently occurs in cells of the inner cell mass (ICM), which give rise to the embryo-proper in which random X inactivation is known to occur. This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okamoto, Ikuhiro -- Otte, Arie P -- Allis, C David -- Reinberg, Danny -- Heard, Edith -- New York, N.Y. -- Science. 2004 Jan 30;303(5658):644-9. Epub 2003 Dec 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS UMR218, Curie Institute, 26 rue d'Ulm, Paris 75005, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14671313" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Animals ; Blastocyst/physiology ; Blastomeres/physiology ; Chromatin/metabolism ; Chromosomes, Mammalian/physiology ; *Dosage Compensation, Genetic ; Embryo, Mammalian/*physiology ; *Embryonic and Fetal Development ; *Epigenesis, Genetic ; Female ; *Genomic Imprinting ; Histones/metabolism ; Male ; Methylation ; Mice ; Morula/physiology ; RNA, Long Noncoding ; RNA, Untranslated/metabolism ; Transcription, Genetic ; X Chromosome/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Reactivation of the paternal X chromosome in early mouse embryos (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-31
    Description: It is generally accepted that paternally imprinted X inactivation occurs exclusively in extraembryonic lineages of mouse embryos, whereas cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivation. Here we show that imprinted X inactivation, in fact, occurs in all cells of early embryos and that the paternal X is then selectively reactivated in cells allocated to the ICM. This contrasts with more differentiated cell types where X inactivation is highly stable and generally irreversible. Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mak, Winifred -- Nesterova, Tatyana B -- de Napoles, Mariana -- Appanah, Ruth -- Yamanaka, Shinya -- Otte, Arie P -- Brockdorff, Neil -- New York, N.Y. -- Science. 2004 Jan 30;303(5658):666-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉X inactivation group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London, W12 0NN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14752160" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Animals ; Blastocyst/physiology ; Cell Cycle Proteins/genetics/metabolism ; Chromosomal Proteins, Non-Histone/genetics/metabolism ; Chromosomes, Mammalian/physiology ; *Dosage Compensation, Genetic ; Embryo, Mammalian/*physiology ; Embryonic and Fetal Development ; Female ; *Gene Expression Regulation, Developmental ; Genomic Imprinting ; Histones/metabolism ; Male ; Methylation ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Morula/physiology ; Polycomb Repressive Complex 2 ; Proteins/genetics/metabolism ; RNA, Long Noncoding ; RNA, Untranslated/genetics/metabolism ; Repressor Proteins/genetics/metabolism ; X Chromosome/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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