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  • Monoamine oxidase type B  (1)
  • maple  (1)
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  • 1
    ISSN: 1432-1041
    Keywords: Monoamine oxidase type B ; Positron emission tomography ; Ro 19-6327 ; Pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight normal subjects (3 females and 5 males) were studied using intravenous L-11C] deprenyl and positron emission tomography. In a single blind study one subject received tracer alone, one subject received an oral pre-dose of 20 mg of L-deprenyl and 6 subjects received oral pre-doses of 10 to 50 mg of a novel reversible MAO-B inhibitor (Ro 19-6327). Dynamic PET scans beginning 12 h after the oral dose were collected over 90 min and arterial blood was continuously sampled. Data analysis was modelled for two tissue compartments and using an iterative curve fitting technique the value of the rate constant for irreversible binding of L-[11C] deprenyl to MAO-B (k3) in whole brain was obtained for each subject. The dose response curves obtained indicated that a dose of at least 0.48 mg·kg−1 of Ro 19-6327 was necessary for 〉90% decrease in whole brain k3. Inhibition of MAO-B in platelets isolated from blood samples taken at the time of scanning correlated strongly with decrease in whole brain k3 (r=0.949). The results indicate that PET can be used to determine the dose of Ro 19-6327 necessary to inhibit 〉90% of brain MAO-B. This technique is an attractive alternative to traditional large scale patient-based dose-finding studies. Moreover it is shown that inhibition of platelet MAO-B can be used as a marker for central MAO-B inhibition with Ro 19-6327.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Agroforestry systems 44 (1998), S. 141-149 
    ISSN: 1572-9680
    Keywords: ash ; maple ; poplar ; soil macro-fauna
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Earthworms are known to increase soil bulk density, soil porosity, mixing of organic matter, and to strengthen aggregation of soil particles. They perform important functions in the maintenance and stabilization of the soil matrix. Historically, temperate intercropping research has focused on the above-ground benefits of adding trees into the agricultural landscape. Earthworm research in temperate intercropping systems has been non-existent to date. More emphasis on studying below-ground components, such as earthworms, is required in order to better understand the mechanisms of intercropping ecosystem function. The purpose of this study was to examine seasonal changes in distribution and abundance of earthworms under a temperate intercropping system in southwestern Ontario, Canada. Sampling occurred during the spring and summer of 1997 at the University of Guelph's Agroforestry Research Station, Guelph, Ontario. Earthworm samples were collected at various distances from the tree rows. Significant variation in both earthworm biomass and density were found between the three tree species sampled. Total mean earthworm density was 182 m-2 within the poplar rows, 71 m-2 within the silver maple rows, and 90 m-2 within the white ash rows. A marked difference was also observed in the distribution of earthworms within the tree rows and the field area. For example, total mean density within the tree rows for poplar was 182 individuals m-2, as compared to total mean densities of 117 and 95 individuals m-2, two metres and six metres into the field from the tree, respectively.
    Type of Medium: Electronic Resource
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