Publication Date:
2006-07-29
Description:
Snake or honeybee envenomation can cause substantial morbidity and mortality, and it has been proposed that the activation of mast cells by snake or insect venoms can contribute to these effects. We show, in contrast, that mast cells can significantly reduce snake-venom-induced pathology in mice, at least in part by releasing carboxypeptidase A and possibly other proteases, which can degrade venom components. Mast cells also significantly reduced the morbidity and mortality induced by honeybee venom. These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Metz, Martin -- Piliponsky, Adrian M -- Chen, Ching-Cheng -- Lammel, Verena -- Abrink, Magnus -- Pejler, Gunnar -- Tsai, Mindy -- Galli, Stephen J -- P50 HL067674/HL/NHLBI NIH HHS/ -- P50 HL67674/HL/NHLBI NIH HHS/ -- R01 AI023990/AI/NIAID NIH HHS/ -- R01 CA072074/CA/NCI NIH HHS/ -- R01 CA72074/CA/NCI NIH HHS/ -- R37 AI23990/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2006 Jul 28;313(5786):526-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5324, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16873664" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bee Venoms/*antagonists & inhibitors/toxicity
;
Carboxypeptidases A/antagonists & inhibitors/*metabolism
;
Cell Degranulation
;
Chymases
;
Crotalid Venoms/*antagonists & inhibitors/metabolism/toxicity
;
Hypothermia/etiology
;
Immunity, Innate
;
Mast Cells/enzymology/immunology/*physiology
;
Mice
;
Mice, Inbred C57BL
;
Peptide Hydrolases/metabolism
;
Peritoneal Cavity/cytology
;
Plant Proteins/pharmacology
;
Protease Inhibitors
;
Serine Endopeptidases/metabolism
;
Viper Venoms/*antagonists & inhibitors/metabolism/toxicity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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