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HPLC determination and antihypertensive effect of metipamide (1988)

Klíma, J. ; Grafnetterová, J. ; Kubelka, Z. ; [et al.]

Springer

Chromatographia 26 (1988), S. 206-208

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ISSN: 1612-1112

Keywords: Column liquid chromatoraphy ; Metipamide ; Blood pressure reduction ; Clinical trials

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Summary Metipamide was monitored during a two month cap period of treatment to determine whether the wholeblood levels estimated by HPLC provide a relevant indicator of the possible accumulation of the drug., We also analysed antihypertensive activity and biochemical changes in blood of twenty hypertonic patients. Result showed that metipamide is an effective, first-line antihypertensive agent, combining statisfactory blood pressure reduction with low frequency of side effects and a simple once-daily dosage regime.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02268152

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