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  • Neurosciences.  (2)
  • Medical sciences.  (1)
  • Toxicology.  (1)
  • 1
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Introduction Food and Brain -- 2. Food and Behavior -- 3. Food and Psychological Wellbeing -- 4. Food and Cognition -- 5. Autism and Food -- 6. Healthy Brains: Types of Food and their Active Pharmacological Ingredients -- 5. Dieting: Importance of Diet and Diet Types -- 6. Nutrigenomics -- 7. Epigenetics -- 8. Gut Microbiota (microbiome) -- 9. Personalized Nutrition -- 10. Vegetables -- 11. Fruits -- 12. Nuts, Seeds and Spices -- 13. Grains [Oats, Barley & Quinoa] -- 14. Seafood [fish like Salmon, Oyster, Sea vegetables (algae)] -- 15. Other -- 16. Autism Management through Food and Diet -- 17. Personalized Nutrition Therapy.
    Abstract: The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.
    Type of Medium: Online Resource
    Pages: XX, 693 p. 111 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030304027
    Series Statement: Advances in Neurobiology, 24
    DDC: 612.8
    Language: English
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  • 2
    Keywords: Toxicology. ; Pharmacology. ; Medical sciences. ; Drug development. ; Pharmacy. ; Pharmaceutical chemistry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Pharmacy. ; Pharmaceutics.
    Description / Table of Contents: Chapter 1. Introduction to Toxicology -- Chapter 2. Laboratory Animal models -- Chapter 3. Toxicology Screening Methods -- Chapter 4. Toxicokinetics -- Chapter 5. Safety Pharmacology -- Chapter 6. Good Laboratory Practice.
    Abstract: This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
    Type of Medium: Online Resource
    Pages: XX, 189 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811660924
    DDC: 615.90072
    Language: English
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  • 3
    Keywords: Neurosciences. ; Proteins. ; Nervous system Diseases. ; Genetics. ; Neuroscience. ; Proteins. ; Neurological Disorders. ; Genetics.
    Description / Table of Contents: Chapter 1. Proteins Commonly Linked to Autism Spectrum Disorder -- Chapter 2. Protein Aggregation and Recycling -- Chapter 3. Neuron Membrane and Trafficking Protein Kinases (PKA&B) involved in ASD -- Chapter 4. Proteomic profiling in children with ASD -- Chapter 5. Molecular Protein biomarkers for developing diagnostics and therapeutic interventions.Gene Regulation in Autism. OR Neurodevelopmental Epigenomics -- Chapter 6. Chromatin and Epigenetic Regulation in ASD -- Chapter 7. Autism and the Scaffolding Protein Neurobeachin -- Chapter 8. Genomic Profiling in ADHD subjects -- Chapter 9. ADHD and Epigenetics Regulation -- Chapter 10. Proteomic Approach in ADHD -- Chapter 11. DHD and the Dopamine Transporter (DAT) -- Chapter 12. Protein Kinases involved in ADHD -- Chapter 13. ADHD and Cell Adhesion Molecule 1 – CAM 1 (CADM1 gene) -- Chapter 14. ASD and Cell Adhesion Molecule Astrotactin -- Chapter 15. Possible therapeutic interventions through proteins in ADHD.
    Abstract: This book comprehensively reviews the proteins associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It also discusses the interactions of the associated-proteins, like bromodomain-containing proteins (BCPs), kinases, synaptic proteins, scaffolding proteins, transcriptional factors, and DNA-binding proteins at the subcellular and molecular levels. The book also explores the potential of these proteins as a druggable target and a biomarker in the neurodevelopmental disorders. The book further explores the recent advancements in understanding the important role of epigenetic factors in predisposition to these diseases. Lastly, it presents genetic factors that lead to variation in gene expression in these diseases, disorders management via diet intervention and the future potential of stem cell therapy.
    Type of Medium: Online Resource
    Pages: XV, 339 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811597817
    Series Statement: Nutritional Neurosciences,
    DDC: 612.8
    Language: English
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