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Structural stability of oligomeric proteins: A mean-field theoretical approach (1997)

Völkel, Armin R. ; Noolandi, Jaan

Springer

Journal of computer-aided materials design 4 (1997), S. 1-8

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ISSN: 1573-4900

Keywords: Proteins ; Thermodynamics ; Protein–solvent interactions ; Mean-field theory

Source: Springer Online Journal Archives 1860-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Abstract We present a mean-field approach for calculating thermodynamic properties(free energies) of protein–solvent systems. We apply this method to thetumor suppressor protein p53, where we study the stability of itstetramerization domain when subjected to site-directed mutagenesis. Acomparison with experimental results is included.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1008676700713

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