Publication Date:
1993-10-15
Description:
Repetitive activation of excitatory synapses in the hippocampus produces a persistent enhancement of synaptic efficiency known as long-term potentiation (LTP). In anesthetized and in freely moving rats, the induction of LTP in the perforant path led to a transient increase in the amount of messenger RNA (mRNA) coding for a presynaptic glutamate receptor (GR33) in dentate granule cells. The amount of GR33 mRNA was increased for at least 5 hours after the induction of LTP but was indistinguishable from control values 1 day after induction. The N-methyl-D-aspartate receptor antagonist 2-aminophosphonovalerate prevented the induction of both LTP and the increase in GR33 mRNA. The amount of GR33 protein was increased in the mossy fiber terminal zone of dentate granule cells 5 hours after the induction of LTP. These results suggest that the induction of LTP in synapses at one stage in a neural network may lead to modification in synaptic function at the next stage in the network.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smirnova, T -- Laroche, S -- Errington, M L -- Hicks, A A -- Bliss, T V -- Mallet, J -- New York, N.Y. -- Science. 1993 Oct 15;262(5132):433-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire de genetique moleculaire de la neurotransmission et des processus neurodegeneratifs, Centre National de la Recherche Scientifique (CNRS), Gif-sur-Yvette, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8105538" target="_blank"〉PubMed〈/a〉
Keywords:
2-Amino-5-phosphonovalerate/pharmacology
;
Animals
;
Electric Stimulation
;
Evoked Potentials
;
Gene Expression
;
Hippocampus/*metabolism/physiology
;
In Situ Hybridization
;
Male
;
RNA, Messenger/genetics/metabolism
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, Glutamate/biosynthesis/*genetics
;
Receptors, Presynaptic/biosynthesis/*genetics
;
Synapses/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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